Tenor saxophonist and New Orleans native Johnny Pennino grew up near legendary Bourbon Street and began to play music when he was five years old. Later he progressed to playing the sax at local teen dances. Pennino has accompanied a number of prominent performers who hail from his home state of Louisiana. He played his wailing sax with artists such as Joe Barry, Ernie K-Doe, Benny Spellman, Bobby Mitchell, the Dixie Cups, Professor Longhair, Barbara George, Al Hirt, the Tick Tocks, and Frankie Ford, among other Louisianians. He also played with such out-of-staters as Dion and the Belmonts and Freddy Fender.
The Louisiana Music Hall of Fame has inducted Pennino into its ranks.