Osadebe started his career when he was 23. He played with the Stephen Amache Band for awhile, then continued his career with the Central Dance Band. In 1964 he started his own band, Soundmakers International. Oasadebe spends most of his time playing highlife music; due to this he is considered to be one of the top highlife musicians. In 1981 he was awarded with a gold disc for the LP Onu Kwulonjo. By the mid-'80s, Osadebe was at the height of his career selling over 700,000 records with his hit album Osondi Owendi.