Clarence Avant's Tabu label, as well as an early beneficiary of producers Jimmy Jam and Terry Lewis, Cherrelle was born Cheryl Norton in 1958 in Los Angeles, California. After her family established a summertime residence in Detroit, Michigan, she met bassist/singer Michael Henderson, who had her appear on "One to One," the closing song on his 1978 album In the Night-Time. Norton subsequently went on tour with Henderson and Luther Vandross.
Norton recorded a demo that came to the attention of Tabu Records owner Clarence Avant, who signed her through her father, an attorney. She took the stage name of Cherrelle, inspired by her boss at a bank where she had worked, who would yell, "Cher-relle, you're late!" Teamed with producers/songwriters Jimmy Jam and Terry Lewis -- Time members who had hits with Tabu's S.O.S. Band -- Cherrelle started with a steady stream of charting singles and albums. Fragile, released in 1984, produced the singles "I Didn't Mean to Turn You On" (a Top Ten R&B hit later covered by Robert Palmer) and "Fragile…Handle with Care" (which reached the Top 40 of the same chart). High Priority, released the following year with more guidance from Jam and Lewis, as well as some additional songwriting and production from Cherrelle's romantic partner Randy Ran, featured the number two R&B hit "Saturday Love," a duet with labelmate Alexander O'Neal.
Cherrelle's third album, Jam and Lewis decided to apply a concept-like LP format as they had with O'Neal's Hearsay -- in this case, a tale of a romantic relationship gone bad. The LP's first single was another Cherrelle/O'Neal duet, "Never Knew Love Like This," which parked at number two R&B for two weeks in early 1988. "Everything I Miss at Home," sporting a loungey jazz-piano feel, went to number one R&B in late 1988. The title track went to number four.
Pebbles' Top 20 R&B hit "Always," she released The Woman I Am, her first album away from Jam and Lewis. Her last charting LP, it featured production by Narada Michael Walden, Heatwave's Derek Bramble, and several others. Three singles charted, with "Tears of Joy" the most successful at number 23 R&B.
Cherrelle appeared on Alexander O'Neal's Love Makes No Sense and Lovers Again albums, and she recorded again with Pebbles on Straight from My Heart, but she didn't release her fifth full-length, the independently released and covers-heavy The Right Time, until 1999. During the 2000s and early 2010s, she continued to tour and frequently performed with O'Neal. Her Tabu albums were given expanded reissue treatments in 2013.