Ysaguirre's longest-lived association was with the legendary arranger/bandleader Don Redman. When Redman left McKinney's Cotton Pickers to form his own band in 1931, Ysaguirre was his bassist; he stayed with Redman until 1940. Ysaguirre began playing his first instrument, the tuba, at the age of 18. From 1917-1919, he played in a military band. He then moved to New Orleans, where in 1922 he played with the cornetist Amos White. He recorded several sides with violinist A.J. Piron's orchestra in New York from 1923-1925. During the mid- to late '20s, he worked with banjoist Elmer Snowden, trombonist Te Roy Williams, and violinist Alex Jackson's Plantation Orchestra. He also spent a brief period with Horace and Fletcher Henderson. Ysaguirre spent the '30s with Redman, recording often on both double bass and tuba. After leaving Redman, he continued to freelance around New York through the late '60s.
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